Trimetazidine-N-oxide

CAT: 0804-HY-135408Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-135408Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM. Trimetazidine is an effective antianginal agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties.

CAS Number

1644530-89-1

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trimetazidine-n-oxide.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(CN2CCN(O)CC2)C(OC)=C1OC

Molecular Formula

C14H22N2O4

Molecular Weight

282.34

References & Citations

[1]Sigmund G, et al. Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches. Drug Test Anal. 2014 Nov-Dec;6 (11-12) :1197-205.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Trimetazidine-N-oxide

CAS Number	1644530-89-1
PubChem CID	145925695
IUPAC Name	1-hydroxy-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
Molecular Formula	C14H22N2O4
Molecular Weight	282.34
XLogP	1
Topological Polar Surface Area	54.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	20
Formal Charge	0
Complexity	284

SMILES

COC1=C(C(=C(C=C1)CN2CCN(CC2)O)OC)OC

InChI

InChI=1S/C14H22N2O4/c1-18-12-5-4-11(13(19-2)14(12)20-3)10-15-6-8-16(17)9-7-15/h4-5,17H,6-10H2,1-3H3

InChIKey

MDAXOLBRJMFWDT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1644530-89-1

CID: 145925695

Formula: C14H22N2O4

MW: 282.34

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	282.34
XLogP3	1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	282.15795719
Monoisotopic Mass	282.15795719
Topological Polar Surface Area	54.4 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	284
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-B0968A-01	Trimetazidine
HY-B0968AR-01	Trimetazidine (Standard)
HY-B0968-01	Trimetazidine (dihydrochloride)
HY-B0968S1	Trimetazidine-d9 (dihydrochloride)
HY-B0968S-01	Trimetazidine-d8 (dihydrochloride)
HY-W066614-01	Trimetazidine impurity 10
HY-B0968R-01	Trimetazidine (dihydrochloride) (Standard)
HY-W127842-01	N, N-Dimethyldecylamine N-oxide
HY-W576312	N, N-Dimethyltryptamine N-oxide
HY-N15707	Isocorydine N-oxide

Alternative Products

Catalog	Name
CS-EO-00145	Trimetazidine N-Oxide
T13203-01	Trimetazidine-N-oxide
CS-O-45790	Trimetazidine n-Oxide Dihydrochloride
AR-T06004-01	Trimetazidine N-Oxide DiHCl
CS-O-52332	N-Nitroso Trimetazidine N-Oxide
CS-O-60331	Trimetazidine-N1-oxide
RM-T132014-01	Trimetazidine Impurity N
TRC-F701400-250MG	N-Formyl Trimetazidine
AR-T03362-01	N-Nitroso Trimetazidine
CS-EO-01065	N-Nitroso-Trimetazidine

Trimetazidine-N-oxide

Chemical Information

Related Products

Alternative Products

Popular Products