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N-Acetylserine

CAT: 0804-HY-134222ASize: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134222ASize:100 mg
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Description
N-Acetylserine (N-Acetyl-L-serine) is a physiological inducer of cysteine biosynthesis and activator of CysB. N-Acetylserine can bind to the CysB apoprotein. N-Acetylserine stimulates cysJIH transcription in vitro. N-Acetylserine can be used in the research of SARS-CoV-2 infection[1][2][3][4].
CAS Number
16354-58-8
Product Name Alternative
N-Acetyl-L-serine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/n-acetylserine.html
Purity
98.0
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
OC[C@@H](C(O)=O)NC(C)=O
Molecular Formula
C5H9NO4
Molecular Weight
147.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Lynch AS, et al. Characterization of the CysB protein of Klebsiella aerogenes: direct evidence that N-acetylserine rather than O-acetylserine serves as the inducer of the cysteine regulon. Biochem J. 1994 Apr 1;299 (Pt 1) (Pt 1) :129-36.|[2]Ostrowski J, et al. Molecular characterization of the cysJIH promoters of Salmonella typhimurium and Escherichia coli: regulation by cysB protein and N-acetyl-L-serine. J Bacteriol. 1989 Jan;171 (1) :130-40.|[3]Gama-Almeida MC, et al. Integrated NMR and MS Analysis of the Plasma Metabolome Reveals Major Changes in One-Carbon, Lipid, and Amino Acid Metabolism in Severe and Fatal Cases of COVID-19. Metabolites. 2023 Jul 24;13 (7) :879. |[4]Franke I, et al. YfiK from Escherichia coli promotes export of O-acetylserine and cysteine. J Bacteriol. 2003 Feb;185 (4) :1161-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

Chemical Information

Acetylserine

N-acetyl-L-serine is an N-acetyl-L-amino acid in which the amino acid specified is L-serine. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a N-acetyl-L-amino acid and an acetyl-L-serine.

CAS Number16354-58-8
PubChem CID65249
IUPAC Name(2S)-2-acetamido-3-hydroxypropanoic acid
Molecular FormulaC5H9NO4
Molecular Weight147.13
XLogP-1.2
Topological Polar Surface Area86.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count10
Formal Charge0
Complexity145
SMILES
CC(=O)N[C@@H](CO)C(=O)O
InChI
InChI=1S/C5H9NO4/c1-3(8)6-4(2-7)5(9)10/h4,7H,2H2,1H3,(H,6,8)(H,9,10)/t4-/m0/s1
InChIKey
JJIHLJJYMXLCOY-BYPYZUCNSA-N
Chemical Structure
2D Structure
2D structure of Acetylserine
CAS: 16354-58-8
CID: 65249
Formula: C5H9NO4
MW: 147.13
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight147.13
XLogP3-1.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass147.05315777
Monoisotopic Mass147.05315777
Topological Polar Surface Area86.6 Ų
Heavy Atom Count10
Formal Charge0
Complexity145
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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