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EST73502

CAT: 0804-HY-134189Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134189Size:1 Each
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Description
EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity[1].
CAS Number
1838622-25-5
UNSPSC
12352005
Target
Opioid Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/est73502.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(F)C=C1CCN(CC2)CCC2(O[C@@H]3C)CN(CC)C3=O
Molecular Formula
C19H26F2N2O2
Molecular Weight
352.42
References & Citations
[1]Mónica García, et al. Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ 1 Receptor Antagonist Clinical Candidate for the Treatment of Pain. J Med Chem. 2020 Oct 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
μ Opioid Receptor/MOR

Alternative Products

CatalogName
M28219-01EST73502
BUP07514-01EST73502 HCl
T9669-01EST73502 hydrochloride

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