Emodic acid

• Description :

  Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].

• Product Name Alternative :

  NSC624610

• UNSPSC :

  12352005

• Target :

  ERK; JNK; MMP; NF-κB; p38 MAPK; VEGFR

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/emodic-acid.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O

• Molecular Formula :

  C15H8O7

• Molecular Weight :

  300.22

• References & Citations :

  [1]Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75 (4) :840-853.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [478-45-5]