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Emodic acid

CAT: 0804-HY-134000Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134000Size:1 Each
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Description
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].
CAS Number
478-45-5
Product Name Alternative
NSC624610
UNSPSC
12352005
Target
ERK; JNK; MMP; NF-κB; p38 MAPK; VEGFR
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/emodic-acid.html
Solubility
10 mM in DMSO
Smiles
OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O
Molecular Formula
C15H8O7
Molecular Weight
300.22
References & Citations
[1]Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75 (4) :840-853.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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