18-Deoxyherboxidiene

• Description :

  18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1].

• Product Name Alternative :

  RQN-18690A

• UNSPSC :

  12352005

• Target :

  SF3B1

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/18-deoxyherboxidiene.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@]1([C@]([C@@H]([C@H](CC)OC)C)([H])O1)C[C@H](C)/C=C/C=C(C)/[C@@H]2[C@@H](C)CC[C@H](CC(O)=O)O2

• Molecular Formula :

  C25H42O5

• Molecular Weight :

  422.60

• References & Citations :

  [1]Hideaki Kakeya, et al. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis. J Antibiot (Tokyo) . 2016 Feb;69 (2) :121-3.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1200128-66-0]