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18-Deoxyherboxidiene

CAT: 0804-HY-133924Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-133924Size:1 Each
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Description
18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1].
CAS Number
[1200128-66-0]
Product Name Alternative
RQN-18690A
UNSPSC
12352005
Target
SF3B1
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/18-deoxyherboxidiene.html
Solubility
10 mM in DMSO
Smiles
C[C@]1([C@]([C@@H]([C@H](CC)OC)C)([H])O1)C[C@H](C)/C=C/C=C(C)/[C@@H]2[C@@H](C)CC[C@H](CC(O)=O)O2
Molecular Formula
C25H42O5
Molecular Weight
422.60
References & Citations
[1]Hideaki Kakeya, et al. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis. J Antibiot (Tokyo) . 2016 Feb;69 (2) :121-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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