18-Deoxyherboxidiene

• Description:

  18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1].

• Product Name Alternative:

  RQN-18690A

• UNSPSC:

  12352005

• Target:

  SF3B1

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/18-deoxyherboxidiene.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]1 ([C@] ([C@@H] ([C@H] (CC) OC) C) ([H]) O1) C[C@H] (C) /C=C/C=C (C) /[C@@H]2[C@@H] (C) CC[C@H] (CC (O) =O) O2

• Molecular Formula:

  C25H42O5

• Molecular Weight:

  422.60

• References & Citations:

  [1]Hideaki Kakeya, et al. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis. J Antibiot (Tokyo) . 2016 Feb;69 (2) :121-3.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1200128-66-0