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Cyclobenzaprine N-oxide

CAT: 0804-HY-133797-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133797-01Size:1 mg
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Description
Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine[1][2][3].
CAS Number
6682-26-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cyclobenzaprine-n-oxide.html
Solubility
10 mM in DMSO
Smiles
C[N+](C)([O-])CC/C=C1C2=CC=CC=C2C=CC3=CC=CC=C\13
Molecular Formula
C20H21NO
Molecular Weight
291.39
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Kitamura S, et al. Reduction of tertiary amine N-oxides by liver preparations: function of aldehyde oxidase as a major N-oxide reductase. Biochem Biophys Res Commun. 1984 Jun 29;121 (3) :749-54.|[2]Kobayashi, et al. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311 (1) : p. 29-35.|[3]Belvedere G, et al. Identification of cyclobenzaprine-10, 11-epoxide and other metabolites after incubation of cyclobenzaprine with rat liver microsomes[J]. Xenobiotica, 1975, 5 (12) : 765-771.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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