Mal-PEG5-PFP ester

CAT: 0804-HY-133210-02Size: 250 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-133210-02Size:250 mg

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Description

Mal-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

CAS Number

1807512-46-4

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mal-peg5-pfp-ester.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCOCCOCCOCCN2C(C=CC2=O)=O

Molecular Formula

C23H26F5NO9

Molecular Weight

555.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl/ether Linkers; PEG Linkers

Chemical Information

Mal-PEG5-PFP

CAS Number	1807512-46-4
PubChem CID	77078348
IUPAC Name	(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Molecular Formula	C23H26F5NO9
Molecular Weight	555.4
XLogP	0.6
Topological Polar Surface Area	110
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	20
Heavy Atom Count	38
Formal Charge	0
Complexity	744

SMILES

C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCC(=O)OC2=C(C(=C(C(=C2F)F)F)F)F

InChI

InChI=1S/C23H26F5NO9/c24-18-19(25)21(27)23(22(28)20(18)26)38-17(32)3-5-33-7-9-35-11-13-37-14-12-36-10-8-34-6-4-29-15(30)1-2-16(29)31/h1-2H,3-14H2

InChIKey

HVQHYQSUANAJJW-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1807512-46-4

CID: 77078348

Formula: C23H26F5NO9

MW: 555.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	555.4
XLogP3	0.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	20
Exact Mass	555.15277222
Monoisotopic Mass	555.15277222
Topological Polar Surface Area	110 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	744
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-130416-01	Mal-PEG2-PFP ester
HY-130568-01	Mal-PEG1-PFP ester
HY-130586-01	Mal-PEG3-PFP ester
HY-126506-01	Mal-PEG4-PFP ester
HY-130454-01	Mal-PEG6-PFP ester
HY-138467-01	Mal-PFP ester
HY-132043-01	Propargyl-PEG5-PFP ester
HY-130420	Azido-PEG5-PFP ester
HY-126999	Bis-PEG5-PFP ester
HY-133574	Mal-amido-PEG3-C1-PFP ester

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Catalog	Name
MBS5769473	Mal-PEG5-PFP ester
T38798	Mal-PFP ester
MBS5800060	Propargyl-PEG5-PFP ester
572953	Bis-PEG5-PFP ester
MBS5768552	Azido-PEG5-PFP ester
T15993	Mal-PEG4-PFP ester
T15983-01	Mal-PEG2-PFP ester
T15988-01	Mal-PEG3-PFP ester
T16002	Mal-PEG6-PFP ester
sc-498199	Mal-PEG5-PFP

Mal-PEG5-PFP ester

Chemical Information

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