(E) -5-Hydroxyferulic acid

• Description :

  (E) -5-Hydroxyferulic acid is the E-isomer of 5-Hydroxyferulic acid (HY-133068) . 5-hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrat[1][2][3].

• CAS Number :

  [110642-42-7]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  COMT

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/e-5-hydroxyferulic-acid.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)/C=C/C1=CC(OC)=C(O)C(O)=C1

• Molecular Formula :

  C10H10O5

• Molecular Weight :

  210.19

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Parvathi K, et al. Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols. Plant J. 2001 Jan;25 (2) :193-202.|[2]Maury S, et al. Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase classes have distinct substrate specificities and expression patterns. Plant Physiol. 1999 Sep;121 (1) :215-24.|[3]Inoue K, et al. Substrate preferences of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferases in developing stems of alfalfa (Medicago sativa L.) . Arch Biochem Biophys. 2000 Mar 1;375 (1) :175-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported