(E) -5-Hydroxyferulic acid

• Description:

  (E) -5-Hydroxyferulic acid is the E-isomer of 5-Hydroxyferulic acid (HY-133068) . 5-hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrat[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  COMT

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/e-5-hydroxyferulic-acid.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (O) /C=C/C1=CC (OC) =C (O) C (O) =C1

• Molecular Formula:

  C10H10O5

• Molecular Weight:

  210.19

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Parvathi K, et al. Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols. Plant J. 2001 Jan;25 (2) :193-202.|[2]Maury S, et al. Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase classes have distinct substrate specificities and expression patterns. Plant Physiol. 1999 Sep;121 (1) :215-24.|[3]Inoue K, et al. Substrate preferences of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferases in developing stems of alfalfa (Medicago sativa L.) . Arch Biochem Biophys. 2000 Mar 1;375 (1) :175-82.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  110642-42-7