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Dimethylamiloride (hydrochloride)

CAT: 0804-HY-132181Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-132181Size:1 Each
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Description
Dimethylamiloride hydrochloride is a Na+/H+ exchanger NHE inhibitor with Ki values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. Dimethylamiloride hydrochloride can be used for pain research[1].
CAS Number
2235-97-4
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Na+/H+ Exchanger (NHE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dimethylamiloride-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(Cl)=C(N(C)C)N=C1N)NC(N)=N.Cl
Molecular Formula
C8H13Cl2N7O
Molecular Weight
294.14
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Masereel B, et al. An overview of inhibitors of Na (+) /H (+) exchanger. Eur J Med Chem. 2003 Jun;38 (6) :547-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Dermatolog Treat. 2023 Dec;34 (1) :2220445.|Cell Metab. 2025 Sep 24:S1550-4131 (25) 00385-7.|Electrophoresis. 2025 Sep 23.

Chemical Information

Dimethylamiloride hydrochloride
CAS Number2235-97-4
PubChem CID11957442
IUPAC Name3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide;hydrochloride
Molecular FormulaC8H13Cl2N7O
Molecular Weight294.14
Topological Polar Surface Area137
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity317
SMILES
CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N.Cl
InChI
InChI=1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H
InChIKey
IIUPTHVVXMBJMQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dimethylamiloride hydrochloride
CAS: 2235-97-4
CID: 11957442
Formula: C8H13Cl2N7O
MW: 294.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight294.14
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass293.0558635
Monoisotopic Mass293.0558635
Topological Polar Surface Area137 Ų
Heavy Atom Count18
Formal Charge0
Complexity317
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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