Thymidine 5′-diphosphate

Thymidine 5′-diphosphate

• CAS Number: 491-97-4
• UNSPSC Description: Thymidine 5′-diphosphate (dTDP) is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP). TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate[1][2].
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/thymidine-5-diphosphate.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1)N([C@H]2C[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)C=C(C)C1=O
• Molecular Weight: 402.19
• References & Citations: [1]Cui Q, et al. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20(10):1286-305. |[2]Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26(11):2225-30.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported