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Thymidine 5′-diphosphate

CAT: 0804-HY-131576Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131576Size:1 Each
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Description
Thymidine 5′-diphosphate (dTDP) is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP) . TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate[1][2].
CAS Number
491-97-4
Product Name Alternative
DTDP
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thymidine-5-diphosphate.html
Solubility
10 mM in DMSO
Smiles
O=C(N1)N([C@H]2C[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)C=C(C)C1=O
Molecular Formula
C10H16N2O11P2
Molecular Weight
402.19
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Cui Q, et al. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20 (10) :1286-305. |[2]Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26 (11) :2225-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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