Heliosupine N-oxide

• UNSPSC Description:

  Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC50 of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA)[1].

• Target Antigen:

  mAChR

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/heliosupine-n-oxide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [O-][N+]12[C@]([C@H](CC2)OC(/C(C)=C\C)=O)([H])C(COC([C@@]([C@@H](O)C)(O)C(C)(O)C)=O)=CC1

• Molecular Weight:

  413.46

• References & Citations:

  [1]T. Schmeller, et al. Allelochemical Activities of Pyrrolizidine Alkaloids: Interactions with Neuroreceptors and Acetylcholine Related Enzymes.Journal of Chemical Ecology volume 23, pages399–416 (1997).

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  31701-88-9