Buspirone N-oxide

• Description :

  Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A) . Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research[1][2].

• Product Name Alternative :

  Bu N-oxide

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Drug Metabolite

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(N(CCCC[N+]1([O-])CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4

• Molecular Formula :

  C21H31N5O3

• Molecular Weight :

  401.50

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Zhu M, et al. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33 (4) :500-7. |[2]Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11 (1) :6094.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor

• CAS Number :

  [220747-81-9]