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APPA

CAT: 0804-HY-131542-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131542-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APPA is an aldose reductase inhibitor. APPA can effectively prevent apoptosis and the symptoms of Streptozotocin -induced diabetes by inhibiting the polyol pathway in rats. APPA has the potential for diabetic nephropathy (DN) research[1].
CAS Number
100750-39-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Aldose Reductase; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/appa.html
Solubility
10 mM in DMSO
Smiles
CC(N1C(C2=CC=CC=C2)=CC(OC(C)=O)=C1)=O
Molecular Formula
C14H13NO3
Molecular Weight
243.26
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhi-Ming Xiu, et al. 1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy. Bioorg Med Chem Lett. 2017 Sep 15;27 (18) :4482-4487.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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