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JF-NP-26

CAT: 0804-HY-131019Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131019Size:1 Each
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Description
JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm) . JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals[1].
CAS Number
2341841-03-8
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jf-np-26.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC(C1=CC=C(N(CC)CC)C=C1O2)=CC2=O)NC3=C(C)C=C(C)N=C3C#CC4=CC=CC(F)=C4
Molecular Formula
C30H28FN3O4
Molecular Weight
513.56
References & Citations
[1]Font J, et al. Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator [published correction appears in Elife. 2018 Jan 08;7:]. Elife. 2017;6:e23545. Published 2017 Apr 11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5

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