DBCO-NH-(CH2)4COOH

DBCO-NH-(CH2)4COOH

• CAS Number: 2375193-74-9
• UNSPSC Description: DBCO-NH-(CH2)4COOH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NH-(CH2)4COOH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dbco-nh-ch2-4cooh.html
• Solubility: 10 mM in DMSO
• Smiles: OC(CCCCC(NCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)=O)=O
• Molecular Weight: 404.46
• References & Citations: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported