8-Isoprostaglandin E2

CAT: 0804-HY-130304Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-130304Size:1 mg
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Description
8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL) -dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway[1][2].
CAS Number
[27415-25-4]
Product Name Alternative
IPE2-III
UNSPSC
12352211
Hazard Statement
H302-H360
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/8-isoprostaglandin-e2.html
Purity
99.0
Solubility
10 mM in DMSO|DMSO : ≥ 100mg/mL
Smiles
CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O
Molecular Formula
C20H32O5
Molecular Weight
352.47
Precautions
P264-P270-P280-P330-P405-P501
References & Citations
[1]Wilson SJ, et al. Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochem Biophys Res Commun. 2007;352 (2) :397-403. |[2]Tintut Y, et al. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL) -dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem. 2002;277 (16) :14221-14226.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TXA2/TP

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