MRT67307 (hydrochloride)

MRT67307 (hydrochloride)

• CAS Number: 2095432-39-4
• UNSPSC Description: MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells[2].
• Target Antigen: Autophagy; IKK; ULK
• Type: Reference compound
• Related Pathways: Autophagy;NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mrt67307-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1CCC1)NCCCNC2=NC(NC3=CC=CC(CN4CCOCC4)=C3)=NC=C2C5CC5.[H]Cl
• Molecular Weight: 501.06
• References & Citations: [1]Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.|[2]Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.|[3]Zhu Z, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. 26.37Cancer Discov. 2014 Apr;4(4):452-65.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported