Integrin-IN-2

• Description:

  Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively[1].

• UNSPSC:

  12352005

• Target:

  Integrin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/integrin-in-2.html

• Purity:

  95.71

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)CC(C1=CC=CC(C2CC2)=C1)NC3=NC=C(OCCC4=NC5=C(CCCN5)C=C4)C=C3

• Molecular Formula:

  C27H30N4O3

• Molecular Weight:

  458.55

• References & Citations:

  [1]Anderson NA, et al. Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis. J Med Chem. 2019 Oct 10;62 (19) :8796-8808.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2378617-67-3]