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VP3.15

CAT: 0804-HY-128879Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128879Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE) 7- glycogen synthase kinase (GSK) 3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS) [1].
CAS Number
1281681-54-6
UNSPSC
12352005
Target
GSK-3; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vp3-15.html
Solubility
10 mM in DMSO
Smiles
N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1
Molecular Formula
C20H22N4OS
Molecular Weight
366.48
References & Citations
[1]Medina-Rodríguez EM, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017 Mar 3;7:43545.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE7
Citation 01
J Biol Chem. 2023 Aug;299 (8) :104991.|J Biol Chem. 2025 Jan 27:108244.|Pennsylvania State University. 2025.

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Alternative Products

CatalogName
T13310-01VP3.15
MBS3610513-01VP3.15 dihydrobromide
A18538-50VP3.15 50mg
A18538-10VP3.15 10mg
A18538-5VP3.15 5mg
A18538-100VP3.15 100mg
A18538-25VP3.15 25mg
A21789-100VP3.15 dihydrobromide 100mg
A21789-50VP3.15 dihydrobromide 50mg
A21789-500VP3.15 dihydrobromide 500mg

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