(R) -Larotrectinib

• Description:

  (R) -Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R) -Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases[1]

• Product Name Alternative:

  (R) -LOXO-101; (R) -ARRY-470

• UNSPSC:

  12352005

• Target:

  Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/r-larotrectinib.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1C[C@H](O)CC1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2

• Molecular Formula:

  C21H22F2N6O2

• Molecular Weight:

  428.44

• References & Citations:

  [1]Julia Haas, et al. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS. WO2010048314A1 (compound 93)

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TrkA

• CAS Number:

  [1223404-68-9]