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(R) -Larotrectinib

CAT: 0804-HY-12866BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12866BSize:1 Each
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Description
(R) -Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R) -Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases[1]
CAS Number
1223404-68-9
Product Name Alternative
(R) -LOXO-101; (R) -ARRY-470
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-larotrectinib.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C[C@H](O)CC1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
Molecular Formula
C21H22F2N6O2
Molecular Weight
428.44
References & Citations
[1]Julia Haas, et al. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS. WO2010048314A1 (compound 93)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA

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