(Rac) -SAG

CAT: 0804-HY-12848ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12848ASize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
(Rac) -SAG is an isoform of SAG (HY-12848) . SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM) . SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].
CAS Number
[364590-63-6]
UNSPSC
12352005
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-sag.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(Cl)C2=CC=CC=C2S1)N(C3CCC(NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4
Molecular Formula
C28H28ClN3OS
Molecular Weight
490.06
References & Citations
[1]Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233 (12) : 9799-9811.|[2]Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99 (22) :14071-6.|[3]Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5 (3) :154-6.|[4]Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13|[5]Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-12848-01SAG
HY-12848B-01SAG (hydrochloride)
HY-12848C-01SAG (dihydrochloride)
HY-157993-01SAG-524
HY-12848S-01SAG-d3
HY-12848R-01SAG (Standard)
HY-12848GSAG (GMP)
HY-P71781-01SAG, Human (P.pastoris, His)
HY-RS12415SAG Human Pre-designed siRNA Set A
HY-RS22944Sag Rat Pre-designed siRNA Set A

Alternative Products

CatalogName
MF-0008877-01(Rac) -SAG
MBS130733-01SAG
M34770-01SAG 21k

Popular Products