Clofezone

• Description :

  Clofezone (Perclusone) is an antirheumatic agent that inhibits collagen formation in rat Chondrus granulomas. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS) [1][2].

• CAS Number :

  [17449-96-6]

• Product Name Alternative :

  Perclusone

• UNSPSC :

  12352005

• Target :

  Collagen

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/clofezone.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(COC1=CC=C(C=C1)Cl)NCCN(CC)CC.O=C(N(N(C2=O)C3=CC=CC=C3)C4=CC=CC=C4)C2CCCC

• Molecular Formula :

  C33H41ClN4O4

• Molecular Weight :

  593.16

• References & Citations :

  [1]Celik CM. Erfahrungen in der Behandlung rheumatoider Erkrankungen mit unterschiedlichen Clofezon-Dosen [Experiences in the management of rheumatoid diseases using different clofezone doses]. Z Rheumatol. 1976 May-Jun;35 (5-6) :240-7. |[2]Brettschneider I, et al. Effect of some antirheumatics on connective tissue components. Arzneimittelforschung. 1976;26 (5) :846-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported