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Clomesone

CAT: 0804-HY-W848341-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W848341-01Size:1 mg
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Description
Clomesone (NSC 338947) is a compound with antitumor activity. Clomesone induces the formation of cross-links between DNA strands in cell lines. Clomesone is inactive against most human colorectal cancer solid tumor cell lines in vitro, has no significant activity against mouse tumors in vivo, and is accompanied by bone marrow suppression. Its pharmacokinetic behavior indicates that it cannot reach effective concentrations at the tumor site.
CAS Number
88343-72-0
Product Name Alternative
NSC 338947; CIEtSoSo
UNSPSC
12352100
Hazard Statement
H302-H315-H319-H335
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clomesone.html
Smiles
O=S(OCCCl)(CS(=O)(C)=O)=O
Molecular Formula
C4H9ClO5S2
Molecular Weight
236.69
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Pre-clinical evaluation of a novel chloroethylating agent, Clomesone|[2]M E Dolan, et al. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl (methylsulfonyl) methanesulfonate. Cancer Res. 1988 Jul 1;48 (13) :3603-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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