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Spicamycin

CAT: 0804-HY-127130Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-127130Size:1 Each
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Description
Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein[1][2].
CAS Number
[87099-85-2]
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bcl-2 Family; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/spicamycin.html
Solubility
10 mM in DMSO
Smiles
OC[C@H](O)[C@]([C@H](NC(CNC(CCCCCCCCCCCCC(C)C)=O)=O)[C@@H](O)[C@H]1O)([H])O[C@@H]1NC2=C3C(N=CN3)=NC=N2
Molecular Formula
C30H51N7O7
Molecular Weight
621.77
References & Citations
[1]Zhang WJ, et al. Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein. Jpn J Cancer Res. 2000 Jun;91 (6) :604-11. |[2]Hayakawa Y, et al. Spicamycin, a new differentiation inducer of mouse myeloid leukemia cells (Ml) and human promyelocytic leukemia cells (HL-60) [J]. Agricultural and biological chemistry, 1985, 49 (9) : 2685-2691.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2

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