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Squarunkin A (hydrochloride)

CAT: 0804-HY-127002ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-127002ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction) . Squarunkin A hydrochloride interferes with the activation of Src kinase in cells[1].
CAS Number
2253744-55-5
UNSPSC
12352005
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/squarunkin-a-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(NC2=C(NCCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)C(C2=O)=O)CC1)OCC.[H]Cl
Molecular Formula
C25H33ClF3N5O4
Molecular Weight
560.01
References & Citations
[1]Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56 (22) :6181-6186.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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