Squarunkin A (hydrochloride)

Squarunkin A (hydrochloride)

• CAS Number: 2253744-55-5
• UNSPSC Description: Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase in cells[1].
• Target Antigen: Src
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/squarunkin-a-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1CCC(NC2=C(NCCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)C(C2=O)=O)CC1)OCC.[H]Cl
• Molecular Weight: 560.01
• References & Citations: [1]Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported