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Desfuroylceftiofur

CAT: 0804-HY-126818Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126818Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desfuroylceftiofur is an active metabolite of Ceftiofur which is a broad-spectrum cephalosporin antibiotic. Desfuroylceftiofur is active against gram-positive and gram-negative bacteria[1][2].
CAS Number
120882-22-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Bacterial; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/desfuroylceftiofur.html
Purity
85.0
Solubility
Ethanol : 10 mg/mL (ultrasonic; warming)
Smiles
O=C(C(N12)=C(CS)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O
Molecular Formula
C14H15N5O5S3
Molecular Weight
429.49
Precautions
H315, H319, H335
References & Citations
[1]Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8 (3) :332-6.|[2]Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372 (1) :73-7.|[3]Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31 (6) :422-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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