Bleomycin A5 (hydrochloride)

Bleomycin A5 (hydrochloride)

• CAS Number: 55658-47-4
• UNSPSC Description: Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death[1][2][3][4]..
• Target Antigen: Antibiotic; Apoptosis
• Type: Natural Products
• Related Pathways: Anti-infection;Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/bleomycin-a5-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: [H]Cl.O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCNCCCCN)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@H](O)[C@H](CO)O5)O)O[C@@]6([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O6)OC(N)=O)O.[x]
• Molecular Weight: 1477.02
• References & Citations: [1]Yang LC, et al. MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med. 2004;33(1):37-45.|[2]Wu F, et al. Bleomycin A5 suppresses Drp1 mediated mitochondrial fission and induces apoptosis in human nasal polyp derived fibroblasts. Int J Mol Med. 2021;47(1):346-360. |[3]Pan JB, et al. Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. Respirology. 2009;14(7):975-982. |[4]He Y, et al. Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway. Molecules. 2016;21(7):862. Published 2016 Jun 30.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported