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PCTR1

CAT: 0804-HY-125445Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-125445Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs) [1].
CAS Number
1810710-59-8
UNSPSC
12352211
Hazard Statement
H225-H319
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pctr1.html
Solubility
10 mM in DMSO
Smiles
CC/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C/C=C\C/C=C\CCC(O)=O)SC[C@H](NC(CC[C@H](N)C(O)=O)=O)C(NCC(O)=O)=O)O
Molecular Formula
C32H47N3O9S
Molecular Weight
649.80
Precautions
P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501
References & Citations
[1]Sesquile Ramon, et al. The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. Am J Pathol. 2016 Apr;186 (4) :962-73.|[2]Brian E Sansbury, et al. PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds. Am J Pathol. 2021 Jun;191 (6) :1049-1063.|[3]Yong-Jian Liu, et al. PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expression. Lab Invest. 2020 Jul;100 (7) :904-915.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
GTR19190732-01PCTR1
208064CDKN2A (Arf, ARF-INK4a, CDK4I, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4), Cyclin-dependent kinase inhibitor 2A isoforms 1/2, Cyclin-dependent kinase inhibitor protein, Ink4a/Arf, INK4a-ARF, Mitochondrial smARF, MTS1, OTTMUSP00000008143, p16, p16 (INK4a), p16-INK4, p16INK4a, p16-INK4a, p19ARF, Pctr1, RP23-166I8.5)

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