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Poloppin

CAT: 0804-HY-124761-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124761-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM) . Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1].
CAS Number
683808-78-8
UNSPSC
12352005
Target
Autophagy; Mitosis; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/poloppin.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCC1=CC=C(C2=CC=C(Br)C=C2)N1C3=CC=CC=C3C(F)(F)F
Molecular Formula
C20H15BrF3NO2
Molecular Weight
438.24
References & Citations
[1]Ana J Narvaez, et al. Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chem Biol. 2017 Aug 17;24 (8) :1017-1028.e7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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