MMSET-IN-1

MMSET-IN-1

• CAS Number: 1998139-29-9
• UNSPSC Description: MMSET-IN-1 is a multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) inhibitor against SETD2 and MMSET with IC50s of 0.49 and 3.3 μM, respectively. MMSET-IN-1 has a Kd of 1.6 μM for MMSET[1].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mmset-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)[C@@H](N)CCC(NCCC)C[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
• Molecular Weight: 423.47
• References & Citations: [1]Tisi D, et al. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. ACS Chem Biol. 2016 Nov 18;11(11):3093-3105.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported