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Oleocanthal

CAT: 0804-HY-124481Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124481Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oleocanthal is an orally active phenolic seciridoid compound. Oleocanthal can be extracted from olive oil. Oleocanthal inhibits COX-1 and COX-2, reduces ROS and NO, and upregulates Nrf-2 and HO-1. Oleocanthal reduces Aβ deposition. Oleocanthal exhibits anti-Leishmania activity against promastigotes and amastigotes of L. major, with IC50 values of 18.7 and 87 μg/mL, respectively. Oleocanthal exhibits anticancer activity against colon, breast, liver, and melanoma cancers. Oleocanthal also exhibits anti-inflammatory and neuroprotective properties. Oleocanthal can be used in Alzheimer's disease research[1][2][3][4][5][6].
CAS Number
289030-99-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; COX; Heme Oxygenase (HO) ; Keap1-Nrf2; NO Synthase; Parasite; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/oleocanthal.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
C/C=C([C@H](CC(OCCC1=CC=C(C=C1)O)=O)CC=O)/C=O
Molecular Formula
C17H20O5
Molecular Weight
304.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Montoya T, et al. Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways. J Agric Food Chem. 2019 May 15;67 (19) :5552-5559.|[2]Iacono A, et al. Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheum. 2010 Jun;62 (6) :1675-82. |[3]Yang E, et al. Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer's Disease. Molecules. 2023 Jul 23;28 (14) :5592.|[4]Uthirapathy S. Anticancer, Anti-inflammatory, and Neuroprotective Effect of Oleocanthal from Virgin Olive Oil–A Review[J]. Integrative Biomedical Research, 2024, 8 (9) : 1-9. |[5]Karampetsou K, et al. Exploring the Immunotherapeutic Potential of Oleocanthal against Murine Cutaneous Leishmaniasis. Planta Med. 2022 Aug;88 (9-10) :783-793.|[6]Costa V, et al. Anti-Inflammatory Activity of Olive Oil Polyphenols-The Role of Oleacein and Its Metabolites. Biomedicines. 2022 Nov 21;10 (11) :2990.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2; HO-1; Leishmania

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