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FR-190809

CAT: 0804-HY-122078Size: 1 EachDry Ice: NoHazardous: No
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Description
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1].
CAS Number
215589-63-2
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/FR-190809.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(S(=O)(C)=O)C=C(C)N=C1S(=O)(C)=O)N(C2CCCCCC2)CC3=CC=C(OC4=CC=C(F)C=C4)C=C3
Molecular Formula
C29H34FN3O6S2
Molecular Weight
603.73
References & Citations
[1]Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[ (fluorophenoxy) benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem. 1998 Oct 22;41 (22) :4408-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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