3-Deazaneplanocin A (hydrochloride) (GMP)

3-Deazaneplanocin A (hydrochloride) (GMP)

• CAS Number: 120964-45-6
• UNSPSC Description: 3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor[1][2].
• Target Antigen: Histone Methyltransferase; Orthopoxvirus
• Type: GMP Small Molecules
• Related Pathways: Anti-infection;Epigenetics
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/3-deazaneplanocin-a-hydrochloride-gmp.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl
• Molecular Weight: 298.73
• References & Citations: [1]Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood. 2009 Sep 24;114(13):2733-43. |[2]Hou P, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341(6146):651-4. |[3]Zhao C, et al. DZNep and UNC0642 enhance in vitro developmental competence of cloned pig embryos. Reproduction. 2018 Apr 1;157(4):359-369.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported