3-Deazaneplanocin A (DZNep) hydrochloride

• Background:

  3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2. Blocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro. Induces apoptotic cell death in cancer cells and inhibits s-adenosylhomocysteine (SAH) hydrolase. Decreases global DNA methylation and enhances Oct 4 expression in chemically induced pluripotent stem cells (CiPSCs) . DZNeP decreased cell migration, which was additionally reduced by DZNeP/gemcitabine combination.

• Description:

  3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor.

• Purity:

  ≥ 98% by HPLC

• Solubility:

  Soluble in Water

• Molecular Formula:

  C12H14N4O3• HCl

• Shipping Conditions:

  Room Temperature (continental US) or Gel Packs

• Storage Conditions:

  Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

• Calculated Molecular Weight:

  298.7 Da

• CAS Number:

  120964-45-6