RU28362

CAT: 0804-HY-121859Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-121859Size:1 Each

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Description

RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CAS Number

74915-64-3

UNSPSC

12352211

Target

Bcl-2 Family; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ru28362.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@@](O)(CC[C@]4([C@@]3(C=C(C2=C1)C)[H])[H])C#CC)C)O)[H])C

Molecular Formula

C23H28O3

Molecular Weight

352.47

References & Citations

[1]Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144 (2) :482-94.|[2]Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18 (2) :129-38.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BNIP3

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GTR19197435-01	RU28362

RU28362

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