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(Rac) -Tanomastat

CAT: 0804-HY-12168BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12168BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Rac) -Tanomastat ((Rac) -BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3].
CAS Number
179545-76-7
Product Name Alternative
(Rac) -BAY 12-9566
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-tanomastat.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C=C1)C2=CC=C(C=C2)C(CC(CSC3=CC=CC=C3)C(O)=O)=O
Molecular Formula
C23H19ClO3S
Molecular Weight
410.91
References & Citations
[1]Leung D, et al. Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43 (3) :305-41.|[2]Gatto C, et al. BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity. Clin Cancer Res. 1999 Nov;5 (11) :3603-7.|[3]Nozaki S, et al. Activity of biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in a human breast cancerorthotopic model. Clin Exp Metastasis. 2003;20 (5) :407-12.|[4]Harold Clinton Eugene Kluender, et al. Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitiors. WO1996015096A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-13; MMP-2; MMP-3; MMP-9

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