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Ascamycin

CAT: 0804-HY-121071Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121071Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively[1][2][3].
CAS Number
91432-48-3
UNSPSC
12352005
Target
Antibiotic; Bacterial; Nucleoside Antimetabolite/Analog
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ascamycin.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]([C@H]([C@H](N1C=NC2=C(N=C(Cl)N=C21)N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)C)=O)=O
Molecular Formula
C13H18ClN7O7S
Molecular Weight
451.84
References & Citations
[1]Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo) . 1984 Jun;37 (6) :670-2.|[2]Osada H, rt al. Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri. Biochem J. 1986 Jan 15;233 (2) :459-63.|[3]Zhao C, et al. Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5'-O-sulfonamide moiety in Streptomyces sp. JCM9888. PLoS One. 2014 Dec 5;9 (12) :e114722.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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