BRD9185

CAT: 0804-HY-120924Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120924Size:1 Each
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Description
BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].
CAS Number
[2057420-29-6]
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/brd9185.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H]([C@H]([C@H]1C#N)C2=CC=C(C3=CC=C(C(C(F)(F)F)=C3)C(F)(F)F)C=C2)CO)NCCC
Molecular Formula
C23H21F6N3O2
Molecular Weight
485.42
References & Citations
[1]Maetani M, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8 (4) :438-442.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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