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Boc-NH-PEG1-CH2CH2COOH

CAT: 0804-HY-120775Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-120775Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].
CAS Number
1260092-44-1
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/boc-nh-peg1-ch2ch2cooh.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
CC(C)(OC(NCCOCCC(O)=O)=O)C
Molecular Formula
C10H19NO5
Molecular Weight
233.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Darren H. Wakefield, et al. Poly (vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1.|[2]Alex Cortez, et al.Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers

Chemical Information

3-(2-{[(Tert-butoxy)carbonyl]amino}ethoxy)propanoic acid
CAS Number1260092-44-1
PubChem CID23591750
IUPAC Name3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]propanoic acid
Molecular FormulaC10H19NO5
Molecular Weight233.26
XLogP0.3
Topological Polar Surface Area84.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count16
Formal Charge0
Complexity234
SMILES
CC(C)(C)OC(=O)NCCOCCC(=O)O
InChI
InChI=1S/C10H19NO5/c1-10(2,3)16-9(14)11-5-7-15-6-4-8(12)13/h4-7H2,1-3H3,(H,11,14)(H,12,13)
InChIKey
YGNSGMAPLOVGIU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(2-{[(Tert-butoxy)carbonyl]amino}ethoxy)propanoic acid
CAS: 1260092-44-1
CID: 23591750
Formula: C10H19NO5
MW: 233.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight233.26
XLogP30.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass233.12632271
Monoisotopic Mass233.12632271
Topological Polar Surface Area84.9 Ų
Heavy Atom Count16
Formal Charge0
Complexity234
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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