BMS-823778 (hydrochloride)

BMS-823778 (hydrochloride)

• CAS Number: 1140898-87-8
• UNSPSC Description: BMS-823778 hydrochloride is a potent, selective and orally active 11β-HSD1 inhibitor with an IC50 of 2.3 nM against human 11β-HSD1[1].
• Target Antigen: 11β-HSD
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/bms-823778-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: CC(O)(C1=CC=CN2C1=NN=C2C3(C4=CC=C(Cl)C=C4)CC3)C.Cl
• Molecular Weight: 364.27
• References & Citations: [1]Li J, et al. Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1). ACS Med Chem Lett. 2018 Nov 13;9(12):1170-1174.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 2