BMS-199264 (hydrochloride)

BMS-199264 (hydrochloride)

• CAS Number: 186180-83-6
• UNSPSC Description: BMS-199264 hydrochloride is an inhibitor of F1F0 ATP hydrolase (IC50=0.5 μM) without inhibitory effect on F1F0 ATP synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion[1].
• Target Antigen: ATP Synthase
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/bms-199264-hydrochloride.html
• Purity: 99.28
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O[C@@H]1C(C)(OC2=CC=C(C=C2[C@H]1N(CC3=NC=CN3)C4=CC=C(C=C4)Cl)S(=O)(N5CCCCC5)=O)C.Cl
• Molecular Weight: 567.53
• References & Citations: [1]Grover GJ, et al. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported