Products for Research Use Only
RegisterLogin

BMS-199264 (hydrochloride)

CAT: 0804-HY-118960-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-118960-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BMS-199264 hydrochloride is an inhibitor of F1F0 ATP hydrolase (IC50=0.5 μM) without inhibitory effect on F1F0 ATP synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion[1].
CAS Number
186180-83-6
UNSPSC
12352005
Target
ATP Synthase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-199264-hydrochloride.html
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1C(C)(OC2=CC=C(C=C2[C@H]1N(CC3=NC=CN3)C4=CC=C(C=C4)Cl)S(=O)(N5CCCCC5)=O)C.Cl
Molecular Formula
C26H32Cl2N4O4S
Molecular Weight
567.53
References & Citations
[1]Grover GJ, et al. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26 (4) :287-96.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(3S,4R)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-2,2-dimethyl-6-(1-piperidinylsulfonyl)-2H-1-Benzopyran-3-ol hy
CAS Number186180-83-6
PubChem CID70202986
IUPAC Name(3S,4R)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-2,2-dimethyl-6-piperidin-1-ylsulfonyl-3,4-dihydrochromen-3-ol;hydrochloride
Molecular FormulaC26H32Cl2N4O4S
Molecular Weight567.5
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count37
Formal Charge0
Complexity841
SMILES
CC1([C@H]([C@@H](C2=C(O1)C=CC(=C2)S(=O)(=O)N3CCCCC3)N(CC4=NC=CN4)C5=CC=C(C=C5)Cl)O)C.Cl
InChI
InChI=1S/C26H31ClN4O4S.ClH/c1-26(2)25(32)24(31(17-23-28-12-13-29-23)19-8-6-18(27)7-9-19)21-16-20(10-11-22(21)35-26)36(33,34)30-14-4-3-5-15-30;/h6-13,16,24-25,32H,3-5,14-15,17H2,1-2H3,(H,28,29);1H/t24-,25+;/m1./s1
InChIKey
CKNXQCNQMADQCI-KGQXAQPSSA-N
Chemical Structure
2D Structure
2D structure of (3S,4R)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-2,2-dimethyl-6-(1-piperidinylsulfonyl)-2H-1-Benzopyran-3-ol hy
CAS: 186180-83-6
CID: 70202986
Formula: C26H32Cl2N4O4S
MW: 567.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight567.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass566.1521321
Monoisotopic Mass566.1521321
Topological Polar Surface Area107 Ų
Heavy Atom Count37
Formal Charge0
Complexity841
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-118960ABMS-199264
HY-105197ABMS-181101 (hydrochloride)
HY-102011A-01BMS-1166 (hydrochloride)
HY-120633ABMS-986104 (hydrochloride)
HY-10518-01BMS-345541 (hydrochloride)
HY-19745BBMS-202 (hydrochloride)
HY-19219ABMS-189664 (hydrochloride)
HY-120643BMS-823778 (hydrochloride)
HY-16111A-01BMS-214662 (hydrochloride)
HY-120631ABMS-538305 (hydrochloride)

Alternative Products

CatalogName
T26843-01BMS-199264 hydrochloride
B5113-50BMS 182874 hydrochloride
A3252-5.1BMS-599626 Hydrochloride
QYB70304-01BMS-182874 hydrochloride
NJD65004-01BMS-1001 hydrochloride
MLB80616-01BMS-582949 hydrochloride
474078BMS 599626 hydrochloride
MBS3603361-01BMS-1166 hydrochloride
TRC-B216170-250MGBMS 823778 Hydrochloride
GW8214-10mgBMS-387032 hydrochloride

Popular Products