MRS1177

CAT: 0804-HY-120090Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120090Size:1 Each
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Description
MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM.
CAS Number
[183721-13-3]
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/MRS1177.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1)NC2=NC3=C(C4=NC(C5=CC=CO5)=NN24)C=C(C=C3)Cl
Molecular Formula
C20H12ClN5O2
Molecular Weight
389.79
References & Citations
[1]Tafi A, et al. Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49 (14) :4085-97.|[2]Cheong SL, et al. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21 (10) :2898-905.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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