Teleocidin A1

• Description:

  Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC) . Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC50=9.2 nM) [1][2].

• Product Name Alternative:

  Lyngbyatoxin A

• UNSPSC:

  12352005

• Hazard Statement:

  H300+H310

• Target:

  PKC

• Type:

  Natural Products

• Related Pathways:

  Epigenetics; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/teleocidin-a1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C/C(C)=C\CC[C@@](C)(C1=C2C3=C(C=C1)N([C@H](C(N[C@@H](CC3=CN2)CO)=O)C(C)C)C)C=C

• Molecular Formula:

  C27H39N3O2

• Molecular Weight:

  437.62

• Precautions:

  P262-P264-P270-P280-P302+P352-P330-P361+P364-P405-P501

• References & Citations:

  [1]Stafford RG, et al. Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A) . Food Chem Toxicol. 1992;30 (9) :795-801. |[2]Youssef DT, Shaala LA, Mohamed GA, et al. 2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res. 2015;29 (8) :703-709.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [70497-14-2]