KMN-80

• UNSPSC Description:

  KMN-80, a derivative of PGE1 (HY-B0131), is a selective and potent agonist of EP4 receptor with an IC50 and a Ki of 3 nM and 2.35 nM, respectively. KMN-80 is against EP3 receptor with an IC50 of 1.4 μM and >10 μM for all other prostanoid receptors[1]. KMN-80 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/kmn-80.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(CCCCCCN(C1=O)[C@H](CC1)/C=C/[C@@H](O)[C@@H](C)CC#CCC)=O

• Molecular Weight:

  363.49

• References & Citations:

  [1]M Li, et al. Prostaglandin E(2) Receptors in Bone Formation. Int Orthop|[2]Thomas A Owen, et al. KMN-159, a Novel EP 4 Receptor Selective Agonist, Stimulates Osteoblastic Differentiation in Cultured Whole Rat Bone Marrow. Gene. 2020 Jul 20;748:144668.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1628759-75-0