Celecoxib-d4

• Description :

  Celecoxib-d4 is the deuterium labeled Desmethyl Celecoxib. Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an?analog?of Celecoxib and with the optimal yield of 75%[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H319, H372, H410

• Target :

  COX; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Immunology/Inflammation; Others

• Field of Research :

  Inflammation/Immunology

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(F)(C1=NN(C2=C([2H])C([2H])=C(C([2H])=C2[2H])S(N)(=O)=O)C(C3=CC=C(C=C3)C)=C1)F

• Molecular Formula :

  C17H10D4F3N3O2S

• Molecular Weight :

  385.40

• Precautions :

  H302, H319, H372, H410

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Vinay Kumar Sthalam, et al. An Integrated Continuous Flow Micro-Total Ultrafast Process System (μ-TUFPS) for the Synthesis of Celecoxib and Other Cyclooxygenase Inhibitors. RETURN TO ISSUEPREVARTICLENEXT

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [544686-20-6]