Celecoxib-d3

• Description:

  Celecoxib-d3 is the deuterium labeled Celecoxib. Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

• Product Name Alternative:

  SC 58635-d3

• UNSPSC:

  12352005

• Target:

  COX

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology; Cancer

• Purity:

  99.0

• Solubility:

  10 mM in DMSO|DMF : ≥ 25mg/mL|DMSO : ≥ 15mg/mL|Ethanol : ≥ 25mg/mL

• Smiles:

  FC (F) (C1=NN (C2=CC=C (C=C2) S (N) (=O) =O) C (C3=CC=C (C=C3) C ([2H]) ([2H]) [2H]) =C1) F

• Molecular Formula:

  C17H11D3F3N3O2S

• Molecular Weight:

  384.39

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Liu DB, et al. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta Pharmacol Sin. 2012 May;33 (5) :682-90.|[3]Penning TD, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5- (4-methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib) . J Med Chem. 1997|[4]Hou XL, et al. Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. Neural Regen Res. 2015 Nov;10 (11) :1836-40.|[5]Suri A, et al. The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer. Oncotarget. 2016 Apr 8.|[6]Pobbati AV, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10 (8) :3622-3635.|[7]Liu C, et al. Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux. Sci Rep. 2018 Mar 7;8 (1) :4108.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  544686-18-2