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I-SAP

CAT: 0804-HY-118044Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-118044Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC) [1][2].
CAS Number
133538-58-6
UNSPSC
12352005
Hazard Statement
H225, H319
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/i-sap.html
Solubility
10 mM in DMSO
Smiles
OC(CCC/C=C\C[C@H]1[C@@](C[C@]2([H])C[C@@H]1N[S](=O)(C(C=C3)=CC=C3I)=O)([H])C2(C)C)=O
Molecular Formula
C22H30INO4S
Molecular Weight
531.45
Precautions
H225, H319
References & Citations
[1]Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5 (1) :1-4. |[2]Schrör K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49 (7) :921-7.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TXA2/TP

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