I-SAP

• UNSPSC Description:

  I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].

• Target Antigen:

  Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/i-sap.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(CCC/C=C\C[C@H]1[C@@](C[C@]2([H])C[C@@H]1N[S](=O)(C(C=C3)=CC=C3I)=O)([H])C2(C)C)=O

• Molecular Weight:

  531.45

• References & Citations:

  [1]Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5(1):1-4. |[2]Schrör K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49(7):921-7.

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  Store at room temperature 3 years

• Clinical Information:

  No Development Reported

• CAS Number:

  133538-58-6