U92016A (hydrochloride)

• Description:

  U92016A hydrochloride is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity[1][2]. U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM) [2].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/u92016a-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCN([C@H]1CC(C2=C(C=C3)NC(C#N)=C2)=C3CC1)CCC.Cl

• Molecular Formula:

  C19H26ClN3

• Molecular Weight:

  331.88

• References & Citations:

  [1]A G Romero, et al. Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J Med Chem. 1993 Jul 23;36 (15) :2066-74.|[2]R B McCall, et al. Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J Pharmacol Exp Ther. 1994 Nov;271 (2) :875-83.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor; mLAG-3

• CAS Number:

  [149654-41-1]