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G-9791

CAT: 0804-HY-116917Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116917Size:1 Each
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Description
G-9791, a poyridone side chain analogue, is a potent PAK inhibitor with Ki values of 0.95 nM and 2.0 nM for PAK1 and PAK2, respectively[1].
CAS Number
1926204-95-6
UNSPSC
12352005
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/g-9791.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=CC=C(N3C=CC=C(C)C3=O)C=C2Cl)=CC4=CN=C(NC)N=C4N1CCC5(F)CN(C)C5
Molecular Formula
C26H26ClFN6O2
Molecular Weight
508.98
References & Citations
[1]Rudolph J, et, al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59 (11) :5520-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1; PAK2

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