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SSR 146977

CAT: 0804-HY-116822Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116822Size:1 Each
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Description
SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM[1].
CAS Number
264618-44-2
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ssr-146977.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C)C)NC1(CCN(CC1)CCC[C@]2(CN(CCC2)C(C3=CC=CC=C3)=O)C4=CC=C(C(Cl)=C4)Cl)C5=CC=CC=C5
Molecular Formula
C35H42Cl2N4O2
Molecular Weight
621.64
References & Citations
[1]Emonds-Alt X, et, al. Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can J Physiol Pharmacol. 2002 May;80 (5) :482-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
NK3R

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